Big Mouth

Nick Kroll

Nick Birch / Maury the Hormone Monster / Coach Steve / Lola Skumpy / Rick the Hormone Monster (voice)

John Mulaney

Andrew Glouberman (voice)

Jessi Klein

Jessi Glaser (voice)

Jason Mantzoukas

Jay Bilzerian (voice)

Maya Rudolph

Diane Birch / Connie the Hormone Monstress (voice)

Fred Armisen

Elliot Birch (voice)

Jordan Peele

Ghost of Duke Ellington (voice)

Andrew Rannells

Matthew (voice)

Joe Wengert

Teacher (voice)

June Diane Raphael

Devin (voice)

Richard Kind

Marty Glouberman (voice)

Jessica Chaffin

Shannon Glaser (voice)

Paula Pell

(voice)

Neil Casey

Lars / Detective Dumont (voice)

Jon Daly

Garrison Keillor / Magician #1 (voice)